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Molecular and micro-architectural mapping of gray matter alterations in psychosis
Paper Details
Published: 2024/09/12
Journal: Molecular Psychiatry
Pages: 1-10
DOI: 10.1038/s41380-024-02724-0
Paper Links
HTMLThis paper explores structural magnetic resonance imaging data from 38,696 healthy controls and 1256 psychosis-related conditions. Using a normative modeling approach, the authors generated centile scores for cortical gray matter (GM) phenotypes, identifying deviations in regional volumes below the expected trajectory for all conditions, with a greater impact on the clinically diagnosed ones, FEP and chronic. Additionally, 46 neurobiological features from healthy individuals were mapped to these abnormal centiles using a multivariate approach. Results revealed that neurobiological features were highly co-localized with centile deviations, where metabolism, cerebral blood flow and neurotransmitter concentrations showed the most consistent spatial overlap with abnormal GM trajectories. Taken together these findings shed light on the vulnerability factors that may underlie atypical brain maturation during different stages of psychosis.
Authors
Isaac Sebenius
Cambridge University
PhD Student
Sarah Morgan
Cambridge University
Departmental Early Career Academic Fellow, Accelerate Programme
N. Garcia-San-Martin
R.A. Bethlehem
A. Mihalik
J. Seidlitz
C. Aleman-Morillo
L. Dorfschmidt
G. Shafiei
V. Ortiz-Garcia de la Foz
K. Merritt