Back to publications
Disrupted functional brain network associated with presence of hallucinations in Parkinsons Disease
Paper Details
Published: 2024/10/30
DOI: 10.1101/2024.09.30.24314594
Paper Links
HTMLBackground Hallucinations negatively impact quality of life in Parkinsons disease, yet their neural mechanisms remain poorly understood, particularly in early disease stages. This study aimed to identify functional connectivity differences associated with visual hallucinations in early Parkinsons Disease and to validate these findings across independent datasets. Resting state fMRI data from two prior independent studies was used. Group differences in functional connectivity were assessed within predefined cytoarchitectonic cortical classes and functional networks, followed by whole-brain analysis using Network-Based Statistics (NBS). Associations with clinical measures, including hallucination severity, motor symptoms, cognition, and attention, were also evaluated. The identified functional subnetwork shows promise as a potential biomarker and therapeutic target for Parkinsons disease psychosis, warranting further investigation and validation in future studies.
Authors
M. Montagnese
M. Mehta
D. Ffytche
M. Firbank
R.A. Lawson
J.P. Taylor